aeroHEALTH announces the manuscript acceptance of in-depth biological mechanism analysis from first joint comprehensive study combining biological effects and aerosol physical/chemical analysis of anthropogenic and biogenic secondary organic aerosols (SOA) in Environment International. In Pardo et al., human bronchial cells BEAS-2B were exposed at Air-Liquid-Interface to soot particles (SP) as well as SOA from β-pinene (βPin) and naphthalene (NAP) adsorbed on SP.
Genome-wide transcriptome responses showed an Nrf2 oxidative stress response, particularly for SOANap-SP. Other signaling pathways, such as redox signaling, inflammatory signaling, and the involvement of matrix metalloproteinase, were identified to have a stronger impact following exposure to SOANap-SP. SOANap-SP also induced a stronger genotoxicity response than that of SOAβPin-SP or SP, which was associated with the higher aromaticity and oxidation state of the SOANap-SP. These findings implications for the assessment of a baseline toxic potential arising from naturally abundant aerosol, such as SOAβPin, and illustrate the different activation of soot particle toxicity by organic coatings originating from biogenic or anthropogenic sources.
Pardo et al.: Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells. doi.org/10.1016/j.envint.2022.107366. (2022)